CHRNB3 Contents See also References Further reading External links Navigation...

5-HT3ABCDEGABAAα1α2α3α4α5α6β1β2β3γ1γ2γ3δεπθGABAA-ρρ1ρ2ρ3α1α2α3α4βα1α2α3α4α5α6α7α9α10β1β2β3β4δε(α3)2(β4)3(α4)2(β2)3(α7)5(α1)2(β4)3 - Ganglion type(α1)2β1δε - Muscle typeZinc-activatedAMPA1234Kainate12345NMDA12A2B2C2D3A3BL1AL1Bδ1δ2P2X1234567


Genes on human chromosome 8Ion channelsNicotinic acetylcholine receptorsMembrane protein stubs


1142108043ENSG00000147432ENSMUSG00000031492Q05901Q8BMN3proteingene






























































CHRNB3
Identifiers
Aliases
CHRNB3, cholinergic receptor nicotinic beta 3 subunit
External IDs MGI: 106212 HomoloGene: 36035 GeneCards: CHRNB3


















Gene location (Human)
Chromosome 8 (human)
Chr. Chromosome 8 (human)[1]

Chromosome 8 (human)
Genomic location for CHRNB3

Genomic location for CHRNB3

Band 8p11.21 Start 42,697,376 bp[1]
End 42,737,407 bp[1]

































Orthologs
Species Human Mouse
Entrez


1142


108043
Ensembl


ENSG00000147432


ENSMUSG00000031492
UniProt


Q05901


Q8BMN3
RefSeq (mRNA)


NM_000749
NM_001347717


NM_027454
NM_173212
RefSeq (protein)


NP_000740
NP_001334646


NP_081730
NP_775304
Location (UCSC) Chr 8: 42.7 – 42.74 Mb Chr 8: 27.37 – 27.4 Mb

PubMed search		 [3] [4]
Wikidata



View/Edit Human View/Edit Mouse

Neuronal acetylcholine receptor subunit beta-3 is a protein that in humans is encoded by the CHRNB3 gene.[5][6]






Contents






  • 1 See also


  • 2 References


  • 3 Further reading


  • 4 External links





See also


  • Nicotinic acetylcholine receptor


References





  1. ^ abc GRCh38: Ensembl release 89: ENSG00000147432 - Ensembl, May 2017


  2. ^ abc GRCm38: Ensembl release 89: ENSMUSG00000031492 - Ensembl, May 2017


  3. ^ "Human PubMed Reference:"..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output .citation q{quotes:"""""""'""'"}.mw-parser-output .citation .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .citation .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/12px-Wikisource-logo.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-maint{display:none;color:#33aa33;margin-left:0.3em}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}


  4. ^ "Mouse PubMed Reference:".


  5. ^ Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID 1505988.


  6. ^ "Entrez Gene: CHRNB3 cholinergic receptor, nicotinic, beta 3".




Further reading


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  • Green WN, Millar NS (1995). "Ion-channel assembly". Trends Neurosci. 18 (6): 280–7. doi:10.1016/0166-2236(95)93915-K. PMID 7571003.


  • Hogg RC, Raggenbass M, Bertrand D (2003). Nicotinic acetylcholine receptors: from structure to brain function. Rev. Physiol. Biochem. Pharmacol. Reviews of Physiology, Biochemistry and Pharmacology. 147. pp. 1–46. doi:10.1007/s10254-003-0005-1. ISBN 978-3-540-01365-5. PMID 12783266.


  • Willoughby JJ, Ninkina NN, Beech MM, et al. (1993). "Molecular cloning of a human neuronal nicotinic acetylcholine receptor beta 3-like subunit". Neurosci. Lett. 155 (2): 136–9. doi:10.1016/0304-3940(93)90691-D. PMID 7690916.


  • Koyama K, Sudo K, Nakamura Y (1994). "Mapping of the human nicotinic acetylcholine receptor beta 3 gene (CHRNB3) within chromosome 8p11.2". Genomics. 21 (2): 460–1. doi:10.1006/geno.1994.1300. PMID 8088849.


  • Elliott KJ, Ellis SB, Berckhan KJ, et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". J. Mol. Neurosci. 7 (3): 217–28. doi:10.1007/BF02736842. PMID 8906617.


  • Groot Kormelink PJ, Luyten WH (1997). "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32". FEBS Lett. 400 (3): 309–14. doi:10.1016/S0014-5793(96)01383-X. PMID 9009220.


  • Navaneetham D, Penn A, Howard J, Conti-Fine BM (1997). "Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses". Cell. Mol. Biol. (Noisy-le-grand). 43 (3): 433–42. PMID 9193799.


  • Groot-Kormelink PJ, Luyten WH, Colquhoun D, Sivilotti LG (1998). "A reporter mutation approach shows incorporation of the "orphan" subunit beta3 into a functional nicotinic receptor". J. Biol. Chem. 273 (25): 15317–20. doi:10.1074/jbc.273.25.15317. PMID 9624109.


  • Sato KZ, Fujii T, Watanabe Y, et al. (1999). "Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines". Neurosci. Lett. 266 (1): 17–20. doi:10.1016/S0304-3940(99)00259-1. PMID 10336173.


  • Boorman JP, Groot-Kormelink PJ, Sivilotti LG (2001). "Stoichiometry of human recombinant neuronal nicotinic receptors containing the β3 subunit expressed in Xenopus oocytes". J. Physiol. 529 Pt 3 (Pt 3): 565–77. doi:10.1111/j.1469-7793.2000.00565.x. PMC 2270211. PMID 11118490.


  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


  • Boorman JP, Beato M, Groot-Kormelink PJ, et al. (2004). "The effects of beta3 subunit incorporation on the pharmacology and single channel properties of oocyte-expressed human alpha3beta4 neuronal nicotinic receptors". J. Biol. Chem. 278 (45): 44033–40. doi:10.1074/jbc.M211719200. PMID 12912995.


  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.




External links




  • CHRNB3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

  • Human CHRNB3 genome location and CHRNB3 gene details page in the UCSC Genome Browser.


This article incorporates text from the United States National Library of Medicine, which is in the public domain.











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