Genes on human chromosome 12SpliceosomeHuman chromosome 12 gene stubs
973353890ENSG00000075856ENSMUSG00000018974Q15020Q9JLI8proteingeneproteinantigenepitopesHLA-A24T lymphocytesimmunotherapyHIV-1snRNPsspliceosomemRNAinteractRNPS1Androgen receptor
| SART3 |
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| Available structures |
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PDB |
Ortholog search: PDBe RCSB
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| List of PDB id codes |
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2DO4, 5JJW, 5JJX, 5CTT, 5CTR, 5JPZ, 5CTQ |
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| Identifiers |
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Aliases |
SART3, DSAP1, P100, RP11-13G14, TIP110, p110, p110(nrb), squamous cell carcinoma antigen recognized by T-cells 3, squamous cell carcinoma antigen recognized by T cells 3, spliceosome associated factor 3, U4/U6 recycling protein |
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External IDs |
MGI: 1858230 HomoloGene: 40977 GeneCards: SART3 |
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| Gene location (Human) |
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Chr. |
Chromosome 12 (human)[1] |
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Band |
12q23.3 |
Start |
108,522,580 bp[1] |
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End |
108,561,400 bp[1] |
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| Gene location (Mouse) |
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Chr. |
Chromosome 5 (mouse)[2] |
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Band |
5|5 F |
Start |
113,742,446 bp[2] |
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End |
113,772,510 bp[2] |
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RNA expression pattern |
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| More reference expression data |
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| Gene ontology |
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Molecular function |
• U6atac snRNA binding
• histone binding
• U4 snRNA binding
• protein binding
• nucleic acid binding
• ubiquitin-specific protease binding
• U6 snRNA binding
• RNA binding
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Cellular component |
• cytoplasm
• Cajal body
• nuclear speck
• U4/U6 x U5 tri-snRNP complex
• nucleoplasm
• U4/U6 snRNP
• U6atac snRNP
• U4atac/U6atac snRNP
• cell nucleus
• ASAP complex
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Biological process |
• mRNA splicing, via spliceosome
• nucleosome assembly
• RNA processing
• spliceosomal tri-snRNP complex assembly
• homeostasis of number of cells
• positive regulation of histone deubiquitination
• hematopoietic stem cell proliferation
• mRNA processing
• spliceosomal snRNP assembly
• cell morphogenesis
• RNA splicing
• regulation of gene expression
• regulation of alternative mRNA splicing, via spliceosome
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Sources:Amigo / QuickGO
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| Orthologs |
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Species |
Human |
Mouse |
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Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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NM_016926
NM_001356621
NM_001356623 |
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RefSeq (protein) |
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NP_058622
NP_001343550
NP_001343552 |
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Location (UCSC) |
Chr 12: 108.52 – 108.56 Mb |
Chr 5: 113.74 – 113.77 Mb |
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PubMed search |
[3] |
[4] |
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| Wikidata |
View/Edit Human |
View/Edit Mouse |
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Squamous cell carcinoma antigen recognized by T-cells 3 is a protein that in humans is encoded by the SART3 gene.[5][5][6][6][7]
The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.[7]
Interactions
SART3 has been shown to interact with RNPS1[8] and Androgen receptor.[9]
References
^ abc GRCh38: Ensembl release 89: ENSG00000075856 - Ensembl, May 2017
^ abc GRCm38: Ensembl release 89: ENSMUSG00000018974 - Ensembl, May 2017
^ "Human PubMed Reference:"..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output .citation q{quotes:"""""""'""'"}.mw-parser-output .citation .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .citation .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/12px-Wikisource-logo.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-maint{display:none;color:#33aa33;margin-left:0.3em}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}
^ "Mouse PubMed Reference:".
^ ab Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (August 1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
^ ab Harada K, Yamada A, Mine T, Kawagoe N, Takasu H, Itoh K (February 2000). "Mouse homologue of the human SART3 gene encoding tumor-rejection antigen". Japanese Journal of Cancer Research. 91 (2): 239–47. doi:10.1111/j.1349-7006.2000.tb00937.x. PMC 5926322. PMID 10761712.
^ ab "Entrez Gene: SART3 squamous cell carcinoma antigen recognized by T cells 3".
^ Harada K, Yamada A, Yang D, Itoh K, Shichijo S (September 2001). "Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation". International Journal of Cancer. 93 (5): 623–8. doi:10.1002/ijc.1391. PMID 11477570.
^ Liu Y, Kim BO, Kao C, Jung C, Dalton JT, He JJ (May 2004). "Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation". The Journal of Biological Chemistry. 279 (21): 21766–73. doi:10.1074/jbc.M314321200. PMID 15031286.
Further reading
.mw-parser-output .refbegin{font-size:90%;margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{list-style-type:none;margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>dd{margin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none}.mw-parser-output .refbegin-100{font-size:100%}
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Yang D, Nakao M, Shichijo S, Sasatomi T, Takasu H, Matsumoto H, Mori K, Hayashi A, Yamana H, Shirouzu K, Itoh K (August 1999). "Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients". Cancer Research. 59 (16): 4056–63. PMID 10463607.
Tanaka S, Tsuda N, Kawano K, Sakamoto M, Nishida T, Hashimoto T, Shichijo S, Kamura T, Itoh K (November 2000). "Expression of tumor-rejection antigens in gynecologic cancers". Japanese Journal of Cancer Research. 91 (11): 1177–84. doi:10.1111/j.1349-7006.2000.tb00902.x. PMC 5926290. PMID 11092984.
Harada K, Yamada A, Yang D, Itoh K, Shichijo S (September 2001). "Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation". International Journal of Cancer. 93 (5): 623–8. doi:10.1002/ijc.1391. PMID 11477570.
Sasatomi T, Suefuji Y, Matsunaga K, Yamana H, Miyagi Y, Araki Y, Ogata Y, Itoh K, Shirouzu K (March 2002). "Expression of tumor rejection antigens in colorectal carcinomas". Cancer. 94 (6): 1636–41. doi:10.1002/cncr.10421. PMID 11920522.
Liu Y, Li J, Kim BO, Pace BS, He JJ (June 2002). "HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110". The Journal of Biological Chemistry. 277 (26): 23854–63. doi:10.1074/jbc.M200773200. PMID 11959860.
Bell M, Schreiner S, Damianov A, Reddy R, Bindereif A (June 2002). "p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor". The EMBO Journal. 21 (11): 2724–35. doi:10.1093/emboj/21.11.2724. PMC 126028. PMID 12032085.
Nottrott S, Urlaub H, Lührmann R (October 2002). "Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins". The EMBO Journal. 21 (20): 5527–38. doi:10.1093/emboj/cdf544. PMC 129076. PMID 12374753.
Nakayama M, Kikuno R, Ohara O (November 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Stanĕk D, Rader SD, Klingauf M, Neugebauer KM (February 2003). "Targeting of U4/U6 small nuclear RNP assembly factor SART3/p110 to Cajal bodies". The Journal of Cell Biology. 160 (4): 505–16. doi:10.1083/jcb.200210087. PMC 2173746. PMID 12578909.
Damianov A, Schreiner S, Bindereif A (February 2004). "Recycling of the U12-type spliceosome requires p110, a component of the U6atac snRNP". Molecular and Cellular Biology. 24 (4): 1700–8. doi:10.1128/MCB.24.4.1700-1708.2004. PMC 344176. PMID 14749385.
Liu Y, Kim BO, Kao C, Jung C, Dalton JT, He JJ (May 2004). "Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation". The Journal of Biological Chemistry. 279 (21): 21766–73. doi:10.1074/jbc.M314321200. PMID 15031286.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Medenbach J, Schreiner S, Liu S, Lührmann R, Bindereif A (September 2004). "Human U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling". Molecular and Cellular Biology. 24 (17): 7392–401. doi:10.1128/MCB.24.17.7392-7401.2004. PMC 506986. PMID 15314151.
Stanĕk D, Neugebauer KM (September 2004). "Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer". The Journal of Cell Biology. 166 (7): 1015–25. doi:10.1083/jcb.200405160. PMC 2172029. PMID 15452143.
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2do4: Solution structure of the RNA binding domain of squamous cell carcinoma antigen recognized by T cells 3
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